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Phase 2 Trial Results: Weight Loss Outcomes in Type 2 Diabetes At the highest 12 mg dose, adults with type 2 diabetes achieved approximately 16.9% mean body weight reduction from baseline at 24 weeks in a randomised, placebo-controlled phase 2 trial published in The Lancet (2023)
Front Behav Neurosci 10:156
Doctors often use these medications to treat type 2 diabetes or help people with obesity lose weight
When used in combination with GLP-1RAs or DPP-4 inhibitors, exogenous insulin is augmented with endogenous, glucose-dependent insulin secretion, allowing the body to compensate for increased carbohydrate intake without increasing the dose of exogenous insulin and, consequently, risk of hypoglycemia [28, 3133]
Future studies will also need to assess the effects of semaglutide on alcohol craving and consumption at higher medication doses and with people with severe alcohol use disorder
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