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Selectivity profiling indicates activity on ERRs with minimal cross-activation of classical ER/ER or unrelated nuclear receptors at concentrations relevant to the ERR program

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Discussion An emerging literature indicates that activating central GLP-1Rs is sufficient to reduce cocaine-seeking behavior 8,14,18 , findings that support translational studies focused on re-purposing GLP-1R agonists to treat CUD 5,22

Yes, active gastrointestinal side effects such as nausea, vomiting, or diarrhea can cause dehydration and electrolyte imbalances that may temporarily defer donation

Tirzepatide and retatrutide both engage this receptor