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Uma Devi et al
Metformin Long-term carcinogenicity studies have been performed in Sprague Dawley rats at doses of 150, 300, and 450 mg/kg/day in males and 150, 450, 900, and 1200 mg/kg/day in females
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Consequence: increased eumelanin synthesis documented in the B16-F10 and MNT-1 cell models
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