2.3 The pathogenesis of MetS-related nephropathy Insulin resistance is the critical feature of MetS, and insulin receptors are expressed in podocytes, tethered cells, renal microvascular endothelial cells, and tubular epithelial cells of the kidney (43)
This outdated practice offers no benefit for this administration route and only increases tissue trauma
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Eligible comparators included placebo or active treatments such as standard care, sodiumglucose cotransporter 2 (SGLT2) inhibitors, finerenone, reninangiotensinaldosterone system (RAAS) inhibitors, or other glucose-lowering agents
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