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Whether this dose should be maintained for long-term treatment is currently being investigated in the BOND study, which evaluates the effects of 12 months of benfotiamine treatment (300 mg twice daily) on morphometric, neurophysiological and clinical parameters in individuals with T2D and mild-to-moderate symptomatic DPN [73]
Beginning with a low dose allows your body to adapt, reducing the chances of side effects like nausea or digestive discomfort
Have anti-nausea strategies ready
"Obesity is a chronic condition and thus requires long-term treatment," says Shalev, who believes the field is moving toward a two-step approach: using a GLP-1 to achieve weight loss, followed by a different medication to help maintain it
"Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight." Diabetes, Obesity and Metabolism , 19(9), 1242-1251
