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It should be noted that recent studies have shown convergence between these two pathways such that AMPK activation is an upstream event of the NRF2-mediated antioxidant response 53
Given that GSH has a molecular weight similar to that of amino acids, a plausible scenario is that when plants experience mechanical damage or insect attack, a large volume of GSH from the intracellular region may surge into the apoplastic region, inducing calcium influx by activation of the GLR3.3 ion channel
European Biophysics Journal
Wyss V, Ganzit GP, Rienzi A
Am J Hum Genet 64 , 15051510 (1999)
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