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The starter dose of the Wegovy pill is now stocked at pharmacies nationwide, with higher doses rolling in shortly after launch, according to the manufacturer and national reporting
While these medications are mainly associated with improved insulin sensitivity and weight loss, researchers are learning that the benefits of these GLP-1 drugs may go well beyond these effects
For example, in one Medicare Plus Blue PPO formulary we reviewed, Trulicity was listed as a tier 3 drug
In 2018 Zheng and colleagues compared the efficacy of SGLT-2i, GLP-1 agonists, and DPP4i on mortality and cardiovascular end points using a network meta-analysis of 236 trials with 176 310 participants, finding that SGLT-2 inhibitors were associated with reduction in all MIs [HR 0.86 (95% CI 0.770.97)] and nonfatal MIs [HR 0.84 (95% CI 0.720.98)] compared with the control groups (Zheng et al., 2018)
Considering the increasing numbers of PTC cases, the expression of GLP-1R in a subset of PTCs is likely to be more significant than the possibility of C cell neoplasms
