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doi: 10.1016/S0140-6736(14)61468-9 132 KimMPlattMJShibasakiTQuagginSEBackxPHSeinoSet al

The drugs interaction with GIP might underlie the impressive results, or it may activate a different pathway than natural GLP-1 when it is bound to the GLP-1 receptor, Papamargaritis says

This gentler approach suits chronic use without the gastrointestinal and cardiovascular concerns associated with long-term anti-inflammatory medication use

Other drugs on the market such as Mounjaro (tirzepatide), which was approved for treating Type 2 diabetes but also seems to help with weight loss, could also see greater interest

These findings are typically discussed within the context of integrated incretin and glucagon receptor activation models, allowing researchers to explore coordinated glucose homeostasis mechanisms