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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years
The studies were not designed to ask what happens when a high-functioning woman with methylation variants, a history of hormonal contraception use, two decades of hypervigilance, compromised gut function, and perimenopause arrives at the threshold of her absorptive capacity
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In this review, we aimed to clarify the effects of ACs in depressive patients and to explore whether ACs might be the biomarkers for the diagnosis of depression and provide new ideas to treat depression
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