A further possibility is that the positive chronotropic effect could be, at least partially, mediated by sympathetic nervous system enhancement, related to the inhibition of the autonomic nervous system [18, 36, 37]
A daily dose of 14 mg of oral semaglutide for 26 weeks resulted in a mean decline in A1C from baseline of -0.8% (treatment-policy estimand) and -1.0% (trial-product estimand)
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