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Initial randomized clinical trials indicate possible reductions in craving and substance intake, though findings are mixed and ongoing studies are needed to determine safety and efficacy in patients with alcohol and other substance use disorders
10.1155/2021/2989974 69 JinZ.GuoP.LiX.KeJ.WangY.WuH
2 Histology of the described cases of lingual melanotic macule reveals increased melanin in the basal cell layer, some pigment-laden macrophages in the dermis, normal number of melanocytes with no or a slight increase of melanin in their interior and variable degrees of hyperkeratosis