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Finally, for each set, we tested whether the proteins in the set were highly ranked in terms of treatment effect relative to proteins not in the set

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(1) for the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) in adults

Also, adding water after initial reconstitution introduces a second opportunity for contamination

Lab Chip 18 , 36063616 (2018) Blutt, S.E., Klein, O.D., Donowitz, M., Shroyer, N., Guha, C., Estes, M.K.: Use of organoids to study regenerative responses to intestinal damage