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Current data indicate that up to 15% of individuals with NAFLD develop NASH
![how does glp-1 stimulates insulin secretion Schematic pathway showing release of by GLP-1. Binding of glp-1_analogs [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/glp1.png?w=600&tok=baf39c)
While effective, its not always easy to adapt toespecially for patients who feel overwhelmed by the equipment or who struggle with long-term compliance
![how does glp-1 stimulates insulin secretion Schematic pathway showing release of by GLP-1. Binding of glp-1_analogs [TUSOM | Pharmwiki]](https://www.frontiersin.org/files/Articles/1590530/xml-images/fcdhc-06-1590530-g002.webp)
Clinical trials consistently show that patients who escalate doses more slowly report milder and shorter-duration side effects
![how does glp-1 stimulates insulin secretion Schematic pathway showing release of by GLP-1. Binding of glp-1_analogs [TUSOM | Pharmwiki]](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41598-017-02838-2/MediaObjects/41598_2017_2838_Fig7_HTML.jpg)
A reduced appetite can aid weight loss, but you still need enough protein
![how does glp-1 stimulates insulin secretion Schematic pathway showing release of by GLP-1. Binding of glp-1_analogs [TUSOM | Pharmwiki]](https://upload.wikimedia.org/wikipedia/commons/6/64/Incretins_and_DPP_4_inhibitors.svg)
Ozempic's influence on weight loss is twofold : it targets the hunger centers in the brain, particularly in the hypothalamus, reducing hunger, appetite, and cravings
![how does glp-1 stimulates insulin secretion Schematic pathway showing release of by GLP-1. Binding of glp-1_analogs [TUSOM | Pharmwiki]](https://www.researchgate.net/profile/Bart-Schueren/publication/225300239/figure/fig1/AS:486737995669506@1493058789341/Mechanism-of-glucose-dependent-GLP1-potentiated-insulin-secretion-in-the-b-cell-AC_Q320.jpg)
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