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Glucagon-like peptide-1 does not have acute effects on central or renal hemodynamics in patients with type 2 diabetes without nephropathy

The development of additional multi-receptor agonists and the optimisation of existing compounds represent ongoing areas of investigation

Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression

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During induction of anaesthesia or in the recovery period, this retained gastric content could be regurgitated and aspirated into the lungs, potentially causing aspiration pneumonitis or pneumonia