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The deviation from linearity is probably due to geometric constraints in the roGFP barrel similar to those described for roGFP1-iR which had been expected to be less reducing than roGFP1-iL due to stabilization of the thiolate anion by the introduced adjacent basic arginine residue (Lohman and Remington, 2008)
Tamoxifen reverses the multi-drug-resistance of an established human cholangiocarcinoma cell line in combined chemotherapeutics
Such combinatorial approaches could improve the penetration of effector cells into the tumor, counteract immune evasion, and increase the durability of anti-cancer responses
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The instant tone-up effect is particularly appreciated, providing an immediate boost in radiance
