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Furthermore, we will discuss the NAD + and its metabolites serving as an essential hub in both physiological and pathophysiological processes and explore the potential of NAD + modulation in the clinical treatment of diseases

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In our analysis, significant weight regain was observed only in the lower baseline BMI subgroups which did not conform to the common understanding, possibly because the enrolled patients were more severely obese and then not well differentiated by the BMI cutoff point, and the limited data in the analysis also reduced the confidence of the result