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NICE Technology Appraisal (TA875) recommends semaglutide for weight management in adults with a body mass index (BMI) of 35 kg/m or above, or 30 kg/m with weight-related complications such as type 2 diabetes, hypertension, or obstructive sleep apnoea
Are semaglutide and tirzepatide stronger than lipotropic injections
However, there was significant variation in estimated CATE among people, with the BCF model indicating a mean glycemic advantage on SGLT2 inhibitor treatment for 48% (n=13,110) of participants and on the glucagaon-like-peptide-1 receptor agonist treatment for 52% (n=14,209) of individuals
The upcoming TRIUMPH-2 (type 2 diabetes) and TRIUMPH-3 (obesity + cardiovascular disease) results will provide more dysesthesia data across different patient populations and longer timeframes
Both medications should be discontinued at least 2 months before a planned pregnancy due to potential fetal risks
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