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FoB persist in the follicles in a quiescent state as they recirculate until activated by recognition of the antigen by their B cell receptors and the T cell-mediated cognate help, whereupon they proliferate and undergo germinal center (GC) reactions 6,17

34 A relative deficiency of anti-proteases, such as 1-antitrypsin, because of their inactivation by oxidants from cigarette smoke or released from inflammatory leucocytes, causes a protease/anti-protease imbalance in the lungs

Moderation is key

Jger et al

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