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Antioxidant biomolecules and their potential for the treatment of difficult-to-treat depression and conventional treatment-resistant depression

26 Over 100 gene loci, including those associated with presynaptic vesicle trafficking (PCLO), dopaminergic neurotransmission (a primary target of antipsychotics), glutamate ionotropic receptor kainate type subunit 5 (GRIK5), and metabotropic glutamate receptor 5 (GRM5), and neuronal calcium signaling such as calcium voltage-gated channel subunit alpha1 E (CACNA1E) and calcium voltage-gated channel auxiliary subunit alpha2 delta1 (CACNA2D1), are found to be associated with an increased risk of MDD by genome-wide association studies

Finding such a clinic and engaging in the course of therapy may be a worthwhile pursuit for those afflicted by severe PVD

Journal of Aging Science , 4(1), 166