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One of these classes (class I ferroptosis-inducing compounds, erastin derivatives) inhibits GPX4 through the depletion of glutathione, and the other (class II ferroptosis-inducing compounds, RSL3 derivatives) inhibits GPX4 directly, without glutathione depletion
Lippincott, Williams & Wilkins, 2013
doi:10.1016/j.mam.2008.05.005 Lu SC (2013) Glutathione synthesis
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