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The medication is typically initiated at a low dose of 0.25 mg weekly, with gradual titration to therapeutic doses of 0.5 mg, 1 mg, or 2 mg weekly, depending on individual response and tolerability
In SYNERGY-NASH, tirzepatide also achieved higher rates of MASH resolution without fibrosis worsening versus placebo, suggesting hepatic benefits [81]
The core of this concept lies in identifying the degenerative functional traits (rather than just abundance shifts) of the microbiota during host aging
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