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In both groups, 56.7% of patients lost at least 5% of baseline weight

But for researchers with pre-existing conditions, those extra beats raise real questions about monitoring, dose adjustment, and long-term safety that deserve thorough answers

The persistence of hyperglycemia in diabetes triggers a sequence of local metabolic, vascular, and neurochemical modifications, which ultimately culminate in vascular disease and microangiopathy [25]

Increased fat burning during exercise continues even during the recovery phase

3 Evolution of GLP-1-based therapeutics 3.1 First-generation GLP-1RAs The development of GLP-1 receptor agonists stemmed from the significant finding that natural GLP-1 had an exceptionally short half-life of about 1.5 to 5 min, due to its rapid degradation by the enzyme DPP-4 (Campbell and Drucker 2013) (Fig