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1 Consequently, while multi-receptor agonists represent a promising future direction in obesity pharmacotherapy, their application in adolescents must be interpreted cautiously, with careful consideration of developmental safety, long-term outcomes, and ethical implications of extrapolating adult data to younger populations

However, patients with decompensated cirrhosischaracterized by complications such as ascites, variceal bleeding, or hepatic encephalopathyrequire careful individualized assessment, as clinical trial data in this population remains limited

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TRACE advises taking breaks from peptides to imitate these natural patterns, helping maintain the body's responsiveness and avoid potential tolerance