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PYY(336) is currently under investigation for use in the treatment of obesity, and it also suppresses appetite 4,9,13,24 Interestingly, exaggerated secretion of GLP-1 and PYY(336) occurs in some gastric bypass (RYGB) surgery patients, and these alterations correlate with long-term appetite suppression and weight-loss that is associated with such surgery 25

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6 The use of GLP-1RAs is also associated with a lower risk of adverse cardiac events, such as myocardial infarction and stroke

doi:10.1016/j.freeradbiomed.2006.06.017 Acknowledgments Aparajita Dey (Principal Investigator) acknowledges the financial support received from Department of Biotechnology, New Delhi, India (RAPID GRANT FOR YOUNG INVESTIGATORS)