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In vivo studies, such as that by Morris et al., used a preclinical model of a high-fat diet in infant rats to mimic insulin resistance, identifying impaired nigrostriatal dopamine function as a consequencea hallmark of PD neuropathology [152]

Role of Exercise Regular physical activity boosts weight loss and improves overall health

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discontinue at least 2 months before planned pregnancy [1] [3] Patients should understand that obesity is a chronic condition with biological underpinnings that persist after weight loss

This competitive architecture creates distinct strategic layers: duopoly incumbents maximizing anti-obesity medication penetration