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A 2026 systematic review found that GLP-1 receptor agonists were associated with increases in testosterone levels, particularly in people with obesity, type 2 diabetes, or functional hypogonadism
This applies to licensed and unlicensed products alike and helps the MHRA monitor the safety of medicines used in the UK
In our analysis of fluoroquinolone-induced and age-related tendinopathy from the IBM MarketScan data, the median administration period of dexamethasone was 12 and 10 days in the fluoroquinolone and older adult cohort, respectively
Brain Beh Immun
caution and clinical monitoring are appropriate People taking insulin or insulin secretagogues (such as sulphonylureas), where the risk of hypoglycaemia may be increased, and dose adjustment of the concomitant agent may be needed Those with active or unstable diabetic retinopathy , given the potential for transient worsening with rapid glycaemic improvement People taking oral medicines with a narrow therapeutic index , where delayed gastric emptying could affect drug absorption Regarding medullary thyroid carcinoma (MTC) and Multiple Endocrine Neoplasia syndrome type 2 (MEN2): animal studies with GLP-1 receptor agonists have shown thyroid C-cell changes, and some regulatory authorities have issued precautionary warnings
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