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Distinguished from earlier GHS peptides (GHRP-6, GHRP-2, hexarelin) by its high selectivity for GH release without significant effects on ACTH, cortisol, prolactin, or aldosterone at GH-stimulating doses

Progress is therefore likely to depend on integrated validation strategy that combine immune competent organoids and patient derived immune cells with minimally perturbative contact reporters, quantitative sensors for local calcium, lipid flux and redox dynamics, and orthogonal spatial proteomics to connect nanoscale organization with stratification features and therapeutic response (239,240)

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constipation (RR = 2.31

While promising, studies on individuals with HS are largely cross-sectional (Table 2), limiting causal inference