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All experiments were performed in compliance with the guidelines set by the Institutional Animal Care and Use Committee (AU-062023-1111-1206), Faculty of Pharmacy, Alexandria University
The most commonly observed adverse events (incidence of 5% and twice that of placebo) were oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation and fecal incontinence
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