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One-week treatment of DIO mice with G49 induces a transient lipid overload in the liver, increases ketogenesis and FGF21 levels Due to the rapid increase (16 h) in circulating FFAs in G49-treated mice (Fig
Carnaby-Mann, G., & Crary, M
This strategy minimizes side effects including cortisol spikes, which are more frequent with direct GH therapy, and lowers the risk of GH overdose
Meanwhile, unmeasured confounding factors in clinical studies can potentially bias the association evidence, as is a common criticism inherent to observational studies
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