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Because Dihexa activates HGF/c-Met signaling , and this pathway is also involved in some types of tumor progression, caution is advised in: Patients with active cancers History of certain malignancies No human data confirms a cancer risk, but Dihexa is best avoided in patients with cancer unless under strict clinical supervision

Florian S, Krehl S, Loewinger M, Kipp A, Banning A, Esworthy S, Chu FF, Brigelius-Flohe R

However, chronic acid reflux, occurring more than twice a week, may indicate GERD

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