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Fournier P, Paleressompoulle D, Esteve Fraysse MJ, Paolino F, Deveze A, Venail F, Norena A
doi: 10.3389/fimmu.2022.905423 200 HobeikaCMukkalaANWangKPollmannNGaneshSCalderon NovoaFet al
Might see anti-inflammatory effects at low doses while tissue repair requires higher doses
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Animal experiments confirmed that dural injection of bone marrow mesenchymal stem cell-derived exosomes miR-367-3p significantly reduced the expression of EZH2 in spinal cord tissues of EAE mice, increased the expression of SLC7A11, GPX4, GSH, and SOD, decreased the levels of Fe 2+ and MDA, inhibited spinal cord iron deposition, ferroptosis, and inflammation, and alleviated spinal cord injury (Fan et al., 2023)
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