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The models were docked into the EM density maps using Chimera v1.15 59 , followed by iterative manual adjustment and rebuilding in COOT 0.9.6 60

This article delineates the mechanistic interplay in PD between S pathology, sirtuin dysregulation, and impaired insulin signaling, illustrating how systemic metabolic dysfunction may contribute to the progression of neurodegeneration

Porbski et al

Evidence Gaps and Expectations: Crucially, patients must understand the experimental nature

The framework prioritised semaglutide and tirzepatide as first-line treatments, based on evidence of 15% weight loss and benefits in complications such as cardiovascular disease and sleep apnoea