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These considerations set the stage for todays Lasker~Debakey Clinical Medical Research Award, as we recognize three scientists, Svetlana Mojsov, Joel Habener and Lotte Knudsen for their remarkable discoveries that have resulted in the development of revolutionary medicines that safely lower blood glucose in diabetics and induce profound weight loss that reduces obesitys comorbidities

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However, the glucose excursion during an IPGTT was only 1520% lower in female N5-WT mice than in N5-Tr and C57BL/6J mice and remained 3.5-times larger than in female C57BL/6N mice

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