Any adjustments should be made collaboratively with your prescribing clinician, who can assess your progress objectively using clinical measurements such as body weight, waist circumference, HbA1c, fasting glucose, and lipid profiles
The conversation covers how our understanding of obesity as a chronic, relapsing disease has changed over the past 30 years, what the new clinical versus preclinical obesity framework means for how we diagnose and treat it, how GLP-1 drugs work and why they've succeeded where earlier medications failed, what the STEP and SELECT trials revealed about the disease-modifying potential of semaglutide, and how patients and clinicians should be thinking about who these drugs are really for
Kulkarni, Sundeep Lakhtakia, Aniruddha Pratap Singh, Rakesh Kalapala, Gregory G
J Endocr Soc 2021:5
Note that some people with more insulin resistance will not lose weight until they're on the slightly higher dose in the second or third month