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Glutamate uptake is critical in maintaining this delicate equilibrium, not only as a means of preventing excitotoxic accumulation but also as a precursor for GABA synthesis [78]

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First, we observed an increased number of activated PSCs in L-arginine-induced AP, which is consistent with findings from a previous report, 63, 64 which demonstrated increased -SMA expression (a marker for activated PSCs) coincided with TGF- 1 activation in this model

Step 2: Preparation of compound of formula-7a EDC.HC1 (17.45 gm) and HOBt (8.14 gm) were added to a pre-cooled mixture of compound obtained in step-1 and tetrahydrofuran (150 ml) at 0-5C

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