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In contrast, 4 weeks of glutamine supplementation (0.4 g/kg) did not show any significant changes in insulin resistance, insulin sensitivity, -cell function, or blood glucose in patients with T1DM [31]

Dorion S, Lambert H and Landry J

NO activates soluble guanylate cyclase [174], resulting in the generation of cGMP, which in turn activates cGKI [175]

While GLP-1 receptor agonists may influence some metabolic pathways, they do not eliminate the fundamental challenge of preserving lean mass during energy deficit

Patients should discuss with their healthcare team which treatment approach best suits their individual circumstances, comorbidities, and treatment goals, recognising that sustainable metabolic health requires a multifaceted, long-term commitment rather than reliance on any single intervention