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Additionally, their specificity remains a concern as they could inhibit other HDAC isoforms leading to unwanted side effects 65,66
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These include nausea, constipation, diarrhea and indigestion
Early diagnosis and comprehensive early intervention are essential to prevent the development of obesity-related morbidities, including metabolic syndrome, diabetes mellitus, obstructive sleep apnea, respiratory failure, pulmonary hypertension, and cardiovascular complications
In laboratory research, semaglutide is studied as a potent GLP-1 receptor agonist with applications in metabolic, endocrine, and cardiovascular research models
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