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GLP-1s slow stomach emptying, which can make it harder to drink large volumes at once, and some people get dehydrated easily (especially if they have nausea or constipation) [anytimefitness.com]

It also has been approved to reduce the risk of MACE in adults with T2D and cardiovascular disease

Together, this developability assessment helps determine whether standard formulation development is sufficient or whether bioavailability-enhancing technology screening is needed to identify the right enabling technology before advancing into animal studies or Phase 1 development

Studies have consistently shown that tirzepatide can provide more weight loss than single-agonist GLP-1 drugs like semaglutide (Ozempic and Wegovy), ranging around 20% lost weight over a years time on average

Diabetic neuropathy: a position statement by the American Diabetes Association