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In a dedicated review article on the lipid-centric vs protein-centric mechanism of action by anesthetics, Eckenhoff [327] drew examples to the fact that the effects seen on membrane properties were detectable at concentrations far above clinical concentrations, with the caveat that these model cell membranes may be poor approximations to real, highly complex biological systems

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10.1016/j.bbamem.2007.08.002 359

2 These numbers should set realistic expectations: measurable structural change in 12 weeks of consistent use, with improvements continuing over 36 months

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