Fras J.P., Guja C., Hardy E., et al
Doctors commonly prescribe these medications alongside other interventions, such as a low calorie diet and an exercise regimen, to promote weight management and reduce blood sugar levels
Additionally, experts say those with more severe gastrointestinal diseases, such as gastroparesis and inflammatory bowel disease (IBD), should avoid these medications
Study designs that require repeated sampling across multiple tissue sites, for example, may lean on IGF-1 LR3's longer window to reduce the number of administrations needed, while designs isolating a single site of injury or load may prefer PEG-MGF specifically because its action stays contained rather than becoming systemic
37 RCTs Meta-Analysis (2020) Weight loss: -1.13 kg BMI: -0.36 points Fat mass: -1.16 kg Waist circumference: -1.24 cm Umbrella Meta-Analysis (2025) Confirms: statistically significant weight loss , especially combined with exercise