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Wegovy is a brand name for semaglutide , a glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for chronic weight management in adults with a body mass index (BMI) of 30 kg/m or greater, or 27 kg/m or greater in the presence of at least one weight-related comorbidity such as type 2 diabetes or hypertension

Phentermine plus topiramate is a combination medicine taken orally that is used to treat obesity along with diet and exercise in those 12 years or older

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31 Florez, H., et al., Impact of metformin-induced gastrointestinal symptoms on quality of life and adherence in patients with type 2 diabetes

also reported that the neuroprotective effects of GLP-1 on reducing MG-induced apoptosis are through transactivation of EGFR and subsequent PI3K/Akt/mTOR/GCLc/redox pathway in PC12 cells 13