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Resistance to chemotherapy and radiotherapy is both intrinsic and acquired: the blood-brain barrier makes delivery of chemotherapeutic drugs to neoplastic cells difficult, and GBM itself is molecularly heterogeneous and often features robust DNA repair mechanisms such as enhanced methylated-DNA-protein-cysteine methyltransferase (MGMT) activity (11)
Protein expression of Nrf2 and its downstream molecules [e.g., NAD(P)H quinone dehydrogenase 1 (NQO1) and HO-1] in endometriotic lesions in a rat model showed an increased level compared with controls (65)
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