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Sharp pain or discomfort persisting overnight indicates excessive stress on healing tissue

People without diabetes lost an average of 20% of their body weight on average over about 16 months, which is a significant amount for a medication

However, high-dose or prolonged unregulated use has been associated with liver stress in some cases

The effect was due to accelerated angiogenesis but not vasodilation, since there was no significant difference of the blood flow in tails and non-ischemic hind limb between the control and BPC 157 groups