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in the New England Journal of Medicine in 2023, enrolled 338 adults with obesity (BMI of 30 or greater, or 27 or greater with a weight-related condition) [3]

In our future work, we will examine the comparative effectiveness of alternative treatment options for obesity in patients who discontinue semaglutide or tirzepatide, to help patients and their clinicians make informed decisions. In the obese group, the average body weight lost before discontinuation was 8.4%, with a regain rate of 0.5% one year later

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