In order to be taken up by the liver it has to be degraded to amino acids. [I also wonder- since glutamate is elevated in metabolic disease, and a residue in the GSH tripeptide, might it be that providing glycine or serine to support synthesis could be preferred over glutathione
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The acetyl group from acetyl-l-carnitine is also responsible for the production of acetylcholine, an important neurotransmitter for optimal mental functioning.* Uses For Acetyl-l-Carnitine Support For Cognitive Function, Memory, And Emotional Well-Being: The efficacy of long-term acetyl-l-carnitine supplementation was determined in a double blind, placebo-controlled, randomized trial involving 130 elderly individuals for a one-year period
Future research incorporating patients genomic information are expected to build better model