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The studies were done on rodents, the b12 isnt available in the kidneys for very long, weeks, not months it seems.and whether humans with b12 deficiency because of a broken system can access this b12 we wont know without further research
PMID: 37507915
PloS Med (2006) 3(3):e46
The most commonly reported adverse events in Phase 2 and Phase 3 trials were gastrointestinal in nature, including nausea, diarrhea, vomiting, and constipation
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