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Over time, metformins ability to treat insulin resistance without weight gain or increased risk of hypoglycemia was recognized, and it was introduced to the US in 1995

The efficacy data assumes perfect adherence to the dosing schedule, referred to as an efficacy estimand, but Novo also reported results using a broader treatment regimen accounting for missed doses or additional weight-loss medications

Data availability The single-nucleus RNA-sequencing data (raw FASTQ files and processed count matrices) generated in this study from mouse hippocampus and dorsal vagal complex have been deposited in the ArrayExpress database at EMBL-EBI under accession code E-MTAB-16829

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That designation requires FDA-registered manufacturing facilities, validated processes, and regulatory oversight that research chemical companies do not have