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Systemic and endothelial inflammation contribute to collagen deposition, interstitial fibrosis and therefore atrial and ventricular remodelling as well as vascular stiffening [9, 10]
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To extend the NO release time and improve the controllability of NO release, various NO donors/precursors have been developed, including RONO 2 , RSNOs, NONOates, and metal NO complexes, which are further loaded into various organic and inorganic biomaterial carriers to create NO delivery systems
Metal(loid)-specificity and -chelation mechanisms MTs exhibit their high affinity for both essential and non-essential metals, where MTs can provide thiols for metal chelation in their reduced state
LPS recognition by TLR4 is helped by LPS-binding protein (LBP) and CD14, with an indispensable contribution of the MD-2 protein stably associated with the extracellular fragment of the receptor [23]
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