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Evidence has been provided that only a small portion of proIGF-1 cleavage occurs intracellularly

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Mood Regulation: Aids in the synthesis of serotonin, a neurotransmitter that influences the mood, which helps prevent mood swings and depression

From our perspective IGF-1, GH, and insulin conform a finely regulated axis that inform cells about the nutritional status of the organism so that they can either undergo apoptosis/senescence/quiescence or, to the contrary, grow and differentiate