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In diet-induced obese mice, 30 days of once-daily subcutaneous dosing limited fat-mass gain to 1.3 g versus 4.7 g in controls, but only at 32 mg/kg/day

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The peptide has a very short plasma half-life of approximately 3 minutes, which influences dosing frequency and timing considerations

The gap exists because the practice expense RVU component is significantly higher in the non-facility setting, where the physician absorbs the overhead costs of running the office